This issue of Neutrosophic Sets and Systems presents a collection of advanced studies in neutrosophy and its applications across various fields, extending concepts like fuzzy sets and logic. The papers address topics related to managing uncertainty, indeterminacy, and ambiguity in complex systems. Key applications include mathematics, such as fixed point theorems and topological spaces, and engineering problems, such as highway asphalt pavement maintenance and traffic management. The issue also explores the use of neutrosophic frameworks in decision-making and evaluation, with articles on e-commerce website quality, supply chain performance, academic teaching assessment, and the evaluation of hotel service quality. Other papers apply the neutrosophic approach to areas like stock market analysis, green technology innovation, and the automated generation of digital media content. The research demonstrates the utility of neutrosophic theory in providing robust and transparent solutions where traditional deterministic models may fall short.